>The aberrant buildup of misfolded proteins is a hallmark of a host of disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's. Aggregates of these toxic proteins wreak havoc on the function of cells, tissues, and organs
>In a recent study, scientists at Harvard Medical School have identified a new mechanism for activating the cell's protein quality-control system and improving its ability to dispose of misfolded proteins, including ones known to cause neurodegenerative diseases.
> the researchers describe how PDE5 inhibitors—which include the erectile dysfunction drugs sildenafil and tadalafil—lower the accumulation of mutant proteins and reduce cell death and anatomical defects in zebrafish models of neurodegeneration.
https://medicalxpress.com/news/2020-07-erectile-dysfunction-drugs-cells-misfolded.html
>In a recent study, scientists at Harvard Medical School have identified a new mechanism for activating the cell's protein quality-control system and improving its ability to dispose of misfolded proteins, including ones known to cause neurodegenerative diseases.
> the researchers describe how PDE5 inhibitors—which include the erectile dysfunction drugs sildenafil and tadalafil—lower the accumulation of mutant proteins and reduce cell death and anatomical defects in zebrafish models of neurodegeneration.
https://medicalxpress.com/news/2020-07-erectile-dysfunction-drugs-cells-misfolded.html
