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Thus, common wisdom is that people with a past history, or even family history, of such disorders should abstain from certain drugs -- altho microdosing seems to be universally safe, but then again, this is uncharted territory. Regardless, unlike the fist type of mental damage, this one seems to be remarkably, but not totally, restricted to classical psychedelics. Ye olde LSD, DMT, mescaline and such. The bulk of their action in the brain seems to be on serotonin receptors which happen to also be involved in psychotic disorders, which reinforces the aforementioned assumption regarding people at risk.
This brings up 3 important notes about the 2nd type of damage. One involves non-psychedelic drugs which can cause hallucinations, which, as far as my knowledge goes, all fall within the dissociative class. In the absence of serious research, reports are all we have, and so far, it seems that the classic substances of this class do not cause this biochemical damage. This would be explained by the fact that these classical, "pure" dissociatives don't interact with the seratonin receptors, and the hallucinations they cause are instead an indirect consequence of the dissociative effect, akin to hallucinations experienced with sensory deprivation. Some drugs, however, exhibit a curiously wide array of effects, which would include "impure" dissociatives which might hit the serotonin receptors, which is the second note I wanted to bring up. Some of these "wide-spectrum" drugs then, supposedly, can do biochemical damage to predisposed people. The third note is about weed. It's mostly harmless, yet it occasionally does cause the 2nd type in someone. My educated guess is that this is caused not by cannabinoids but by volatile oils which contribute to their effect. A few of them can have psychedelic effects, but the odds of a predisposed person smoking the rare bud with those oils, well that would explain why it's very unlikely yet keeps happening.
