>>11826667Free fatty acids can just as easily come from our own fat stores when dietary fats are low. It's a chicken or the egg situation. Glucose can't enter the cells, which causes a release of free fatty acids, which increases insulin resistance. Regardless, there's a difference between transient diabetes (a high fat meal will increase insulin resistance, it wants to burn the fats first, then the glucose, then normalizes), and true diabetes where free fatty acids are chronically elevated, which is either due to a lack of insulin or insulin resistance even in the absence of food.
>>11828227This sounds like an oversimplification. Assuming the diet isn't awful, abnormal mineral levels are often caused by disregulation of the minerals due to some underlying cause. For example, Wilson's Disease causes an accumulation of copper in the liver, yet they end up with all the issues of NAFLD.
>>11829274>>11829455Manganese is equally effective at blocking iron absorption.
https://pubmed.ncbi.nlm.nih.gov/2058577/Yes, too much iron can be bad. One only needs to look at hemochromatosis to see that. In fact your mouse models used this to study the effects. Yet you can find cases of diabetes without excess levels of iron. You also need to differentiate between diabetes caused by insulin resistance (and why), and diabetes caused by insufficiency (and why).
