Possible drug for COVID19 treatment.
No.11825638 ViewReplyOriginalReport
Quoted By: >>11825671 >>11826167
Dear guys. Today, I am really worried about saving lives.
As many of you already know, COVID19 is a virus, a RNA virus, that gets into the cells trough ACE receptors MAINLY. Once it is inside, it turns the cell into a virus production unit.
There have been many efforts, and research topics towards a cure, however, so far, there is none.
For the cell to became a virus production unit, it must enter into a high metabolic state, and most of the changes within, relies on the cells own citoeskeleton. RNA transport is one of the keys to virus replication process and it NEEDS microtubules.
Albendazole is an anti-parasitic drug, its action mechanism is binding to tubulin, and interfere with its polimerization, inmovilizing the parasite and therefore, killing it. Tubulines are present in the eucaryotic cell. We have tubulin. Our cells have tubulin.
We could use this principle, to give albendazole to infected cells, screw up or slow down virus production process, since it must use tubulin (microtubules) to replicate. This slow down might make the infection milder, lowering virus virulence, giving chance to tne immune system to catch up, avoiding citokyne storm.
There are studies that show that Albendazole is a Coronavirus inhibitor, it also inhibits HIV-1 infection.
It is extremely cheap. in my country, you could get a unique dosis 20 mL (2g/100ml) for less than USD 0.50. Beside that, it is a very safe drug. (Not for pregnant women nor small childs).
Shouldn´t albendazole be considered for treatment or further studies?
As many of you already know, COVID19 is a virus, a RNA virus, that gets into the cells trough ACE receptors MAINLY. Once it is inside, it turns the cell into a virus production unit.
There have been many efforts, and research topics towards a cure, however, so far, there is none.
For the cell to became a virus production unit, it must enter into a high metabolic state, and most of the changes within, relies on the cells own citoeskeleton. RNA transport is one of the keys to virus replication process and it NEEDS microtubules.
Albendazole is an anti-parasitic drug, its action mechanism is binding to tubulin, and interfere with its polimerization, inmovilizing the parasite and therefore, killing it. Tubulines are present in the eucaryotic cell. We have tubulin. Our cells have tubulin.
We could use this principle, to give albendazole to infected cells, screw up or slow down virus production process, since it must use tubulin (microtubules) to replicate. This slow down might make the infection milder, lowering virus virulence, giving chance to tne immune system to catch up, avoiding citokyne storm.
There are studies that show that Albendazole is a Coronavirus inhibitor, it also inhibits HIV-1 infection.
It is extremely cheap. in my country, you could get a unique dosis 20 mL (2g/100ml) for less than USD 0.50. Beside that, it is a very safe drug. (Not for pregnant women nor small childs).
Shouldn´t albendazole be considered for treatment or further studies?
