Here's my situation
>finished my degree in biochem
>/g/ cross poster and programmer
>find bioinformatics really interesting, completed a short research project in it and decide to enter the field
>can't seem to land any interviews at jobs because they all want prior experience or PhDs
>apply for as many PhDs as possible, because straight up bioinformatics projects are very rare
>get a few interviews
>offered a place on a decent project, not my first choice though
>offer has a time limit so i accept
>a month later, I get a second offer on my first choice

So bail on my first offer without being an asshole? I felt cornered when my first offer came through, since it had a time limit and these projects are quite rare. Its not like its a shitty project, I would quite happily do it, but it wasn't my first choice. I also told them that I had applied for other projects at the time my offer came through.

Another factor is that I'm in a niche discipline, so I feel like these researchers likely talk among themselves and I don't want to start off with a bad reputation.

Gimme advice /sci/