Negative health effects of fluoride

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Fluorides are present in the environment naturally, and in artificial products and industrial processes.
Toothpaste, mouthwash, Teflon, pesticides, medicines, anaesthetics, glass etchant, large scale electrical equipment, uranium processing, dental filling materials, desensitising varnish and refrigerants all make use of fluorides.
Is there any substantiated, unbiased and unconfounded evidence of negative health effects from low levels of exposure to fluorides?
I am debating someone on this and they are defending outdated literature with poor quality evidence that suggests adverse effects.