>>11698739Looks like it crosses the blood-brain barrier and actually is prescribed for parkinsons. According to
https://pubmed.ncbi.nlm.nih.gov/26805402/ it doesn't seem to have any negative consequences with long term usage. I found some other articles claiming that it eventually became ineffective for parkinsons after 2 years of being administered-- so I'd imagine whatever benefit you get from it as a supplement would mirror that.