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They cause regular interruption. Imagine the timing signal for a CRT is fucked up, but then that the fuck timing signal is recycled, so the fuckups build up and get worse until they reach some point of stability. With lower doses, this stability point is quickly reached, the interrupt is mostly accounted for. At higher doses the brains attempt to fix itself plays into the errors and only further fucks its world model. A "breakthrough" is reaching this point, at which whole new stable states exist only beyond this state. Its hard to say much about beyond that since I havent experienced it, and even those who have have trouble describing (the pre breakthrough stuff is already indescribable enough).
