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Nicotinamide mononucleotide ("NMN", "NAMN", and "?-NMN") is a nucleotide derived from ribose and nicotinamide.[1] Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).[1] In mice, NMN enters cells via the small intestines within 10 minutes converting to NAD+ through the Slc12a8 NMN transporter.[2] Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.[3][4] Dietary supplement companies have aggressively marketed NMN products claiming those benefits.[5] Doses of up to 500 mg was shown safe in men in a recent human study[6] at Keio University School of Medicine, Shinjuku, Tokyo Japan. Multiple long-term human studies are underway.[7] [8]
