>This was suggestive of possible antibody-dependent enhancement (ADE) of SARS-CoV-2 infection. The immunopathological effects of ADE have been observed in various viral infections, characterized as antibody-mediated enhancement of viral entry and induction of a severe inflammatory response. Worryingly, it was shown that a neutralizing monoclonal antibody targeting the receptor-binding domain of the spike protein of the related Middle East respiratory syndrome (MERS) virus can enhance viral entry. A potential pathogenic effect of antibodies targeted at SARS-CoV-2 would be of major concern for vaccine development and antibody-based therapies. Additional independent large-cohort studies are needed to substantiate or dismiss this possibility.
To virus fags: How big of a deal is this if true? Would this apply to all coronavirus antibodies? And what are the prospects for immunity and vaccination if so?
Source: https://archive.is/UQYvT
To virus fags: How big of a deal is this if true? Would this apply to all coronavirus antibodies? And what are the prospects for immunity and vaccination if so?
Source: https://archive.is/UQYvT
