Localize Genetic Edits

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Is there a way to control mosaicism with any level of accuracy? I'm trying to write up a procedure in which a human patient receives a series of genetic tweaks and methylations, but I need it localized in a very precise region of the body.
Maybe I could encode prefixes into the payload sequence that perform a similar function to plants to regulate behavior, like this:
https://www.sciencedaily.com/releases/2018/06/180619164208.htm
I'm a college dropout and genetics is certainly not my strong suit, my goal is to write up potential procedures and submit them to people who actually know what they're doing. What are your thoughts?