>>11502492* If it had been manipulated by inserting foreign genes then we would already know because it has been sequenced, lots of people are looking at it, and somebody would have realized some gene comes from a very distant strain.
* If it had been genetically manipulated with rational protein design without using pre-existing genes then it is unlikely we will notice.
* If it had been “bred” for high infectiousness and moderate pathogenic using natural mutations (like cattle and crop plants were prior to 20th century), then it is impossible to notice on scientific methods.