>>11498308first week significant increase in attentional resources, energy and libido for the first four hours, extended release there's a second wind around the 5-6 hour mark, a fairly significant rapid loss of motivation and ability to focus by the 8 hour mark dipping well below what you're accustomed to. Reduced appetite will last well into dinner time, and you may feel mildly apathetic at night, so avoid pushing work into the period where the medication wears off. By the third or fourth week you'll see dopamine blunting, less response to typical sources of pleasure like drugs and jerking off, continued appetite suppression, maybe some mild sleep disturbance, the window of productivity shrinks to around 3 hours from the 5-6 you get after withdrawing/abstaining. You should consider taking weekends off or more efficient schedule a week or so every 6 weeks to get off the meds. It won't make you more intelligent but is invaluable for long study sessions.