Thoughts on NSAID use when having the Flu or Coronavirus?
From what I've learned from undergrad biology courses it makes more sense to allow your body to fight off the virus than to use an NSAID to lower your temperature, which may end up doing more harm than good.
>https://www.sciencedirect.com/science/article/pii/S0140673609612083
>Although febrile reactions significantly decreased, prophylactic administration of antipyretic drugs at the time of vaccination should not be routinely recommended since antibody responses to several vaccine antigens were reduced.
>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/
>In conclusion, we report that a panel of widely used NSAIDs blunts antibody synthesis in human PBMCs and in purified B cells. Ibuprofen’s ability to reduce antibody production was concentration- and time-dependent and likely occurred via Cox-2 inhibition. Our results call for awareness regarding the consequences that NSAIDs can have on immunity. NSAIDs are one of the most commonly used drugs; they are recommended for all age categories, are prescribed for relieving transient pain or in cases of serious inflammatory diseases. By decreasing antibody synthesis, NSAIDs also have the ability to weaken the immune system which can have serious consequences for children, the elderly and the immune-compromised patients.
>https://www.ncbi.nlm.nih.gov/pubmed/16433601/
>CONCLUSIONS: Aggressively treating fever in critically ill patients may lead to a higher mortality rate.
>https://www.bmj.com/rapid-response/2011/10/29/coronavirus-may-be-killed-higher-body-temperature
>https://www.ncbi.nlm.nih.gov/pubmed/8698984
Anyone with extensive knowledge of infectious disease have any thoughts about this?
From what I've learned from undergrad biology courses it makes more sense to allow your body to fight off the virus than to use an NSAID to lower your temperature, which may end up doing more harm than good.
>https://www.sciencedirect.com/science/article/pii/S0140673609612083
>Although febrile reactions significantly decreased, prophylactic administration of antipyretic drugs at the time of vaccination should not be routinely recommended since antibody responses to several vaccine antigens were reduced.
>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/
>In conclusion, we report that a panel of widely used NSAIDs blunts antibody synthesis in human PBMCs and in purified B cells. Ibuprofen’s ability to reduce antibody production was concentration- and time-dependent and likely occurred via Cox-2 inhibition. Our results call for awareness regarding the consequences that NSAIDs can have on immunity. NSAIDs are one of the most commonly used drugs; they are recommended for all age categories, are prescribed for relieving transient pain or in cases of serious inflammatory diseases. By decreasing antibody synthesis, NSAIDs also have the ability to weaken the immune system which can have serious consequences for children, the elderly and the immune-compromised patients.
>https://www.ncbi.nlm.nih.gov/pubmed/16433601/
>CONCLUSIONS: Aggressively treating fever in critically ill patients may lead to a higher mortality rate.
>https://www.bmj.com/rapid-response/2011/10/29/coronavirus-may-be-killed-higher-body-temperature
>https://www.ncbi.nlm.nih.gov/pubmed/8698984
Anyone with extensive knowledge of infectious disease have any thoughts about this?
