https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/
> "Pseudotyping experiments were based on HIV-based pseudovirus"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/pdf/nihms766724.pdf
https://www.nature.com/articles/nm.3985
Nature full PDF: https://files.catbox.moe/bbamzm.pdf
> gain-of-function
> "We built a chimeric virus encoding a novel, zoonotic CoV spike protein from the RsSHC014-CoV sequence that was isolated from Chinese horseshoe bats in the context of the SARS-CoV mouse-adapted backbone. We characterized CoV infection mediated by the SHC014 spike protein in primary human airway cells and in vivo."
> Xing-Yi Ge
> Zhengli-Li Shi
> + funding from China:
> "National Natural Science Foundation of China awards 81290341 (Z.-L.S.) and 31470260 (X.-Y.G.)."
https://www.the-scientist.com/news-opinion/lab-made-coronavirus-triggers-debate-34502
> “The only impact of this work is the creation, in a lab, of a new, non-natural risk,” Richard Ebright, a molecular biologist and biodefence expert at Rutgers University, told Nature.
> "Pseudotyping experiments were based on HIV-based pseudovirus"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/pdf/nihms766724.pdf
https://www.nature.com/articles/nm.3985
Nature full PDF: https://files.catbox.moe/bbamzm.pdf
> gain-of-function
> "We built a chimeric virus encoding a novel, zoonotic CoV spike protein from the RsSHC014-CoV sequence that was isolated from Chinese horseshoe bats in the context of the SARS-CoV mouse-adapted backbone. We characterized CoV infection mediated by the SHC014 spike protein in primary human airway cells and in vivo."
> Xing-Yi Ge
> Zhengli-Li Shi
> + funding from China:
> "National Natural Science Foundation of China awards 81290341 (Z.-L.S.) and 31470260 (X.-Y.G.)."
https://www.the-scientist.com/news-opinion/lab-made-coronavirus-triggers-debate-34502
> “The only impact of this work is the creation, in a lab, of a new, non-natural risk,” Richard Ebright, a molecular biologist and biodefence expert at Rutgers University, told Nature.
