>>11419043Great question! We are certainly trying to speed things up. I mention 2030 because that is the public timeline that most other xeno companies are talking about in terms of what's feasible.
To speed things up, we are making multiple edits separately on the same cell line (PAM cells). Doing this lets us determine how each edit leads to a reduced immune rejection when we culture the PAM cells with human T-cells and antibodies to study the speed of rejection.
Again, I'm happy to get into what those exact edits are. But once we figure out which ones lead to a negligible immune response, we can grow the edited pig embryo into a full animal. Then we'll perform preclinical trials for a bunch of different organs at once. If we can prove one pig can produce many kinds of effective organs, that will speed up our application to the FDA to get multiple organs into clinical trial.
