Psychedelic microdosing is, far and away, both the cheapest and the most effective treatment. It's not guaranteed to work, of course, but microdosing really is statistically more likely to work than the current generation of meds, and this much is a fact.
The new, 3rd generation of antidepressants will just plain abandon the decades-long dominant paradigm of depression being caused by some sort of serotonin depression, which has turned out to be pure bunk. OOPSIE DOODLE. The first one already arrived. In fact, it arrived decades ago. It's ketamine. Like, it's not even an evergreen analog or anything, it's just plain one of ketamine's two stereoisomers, and in order to try to mask this absurdity, they have taken to call it "esketamine" instead of the more appropriate S-ketamine. As it happens, this isomer seems to be responsible for all the fun effects of the drug, but not the antidepressant effect. So why are they using this one, you might ask? Simply because it's the one the company in question had a patent on. That's it. More attentive readers might be asking, well if they can't use the other stereoisomer thingamajig, why not just use regular, mixed ketamine? Because it's in the public domain, so to speak, and can't be patented. A drug which is a borderline miracle cure for what just might turn out to be the biggest epidemic in mankind's history, just lying fallow because it's not profitable. S-ketamine -- sorry, esketamine, on the other hand, still is, so that's what you get, peasant. And since the antidepressant effect is so weak, you get a big-ass dose, which means you trip your tits off. The Man doesn't like that, so you can't buy it. You go to a clinic every 3 days to trip. Drug as a service. I'm not joking, google Spravato and you'll see. Oh, and this costs thousands of dollars, which is hundreds more than run-of-the-mill ketamine which your pet can legally use.
And you thought notions about Big Pharma profiting from misery were conspiracy theory, eh?
