What is /sci/s opinion on nootropics? Are they placebo, or are they actually useful?

In particular, Qualia Focus. Here is the list of ingredients in it:


NOOTROPIC COMPOUNDS
Huperzine A
Celastrus Paniculatus Seed Extract
Theobromine
Uridine Monophosphate
Coffeeberry® (caffeine)

VITAMINS
Vitamin D3 (Cholecalciferol)
Vitamin C (Ascorbic Acid)
Niacin (as Niacinamide)
Vitamin B1 (Thiamine)
Vitamin B6 (Pyridoxal-5-Phosphate)
Vitamin B12 (Methylcobalamin)
Vitamin B5 (Calcium Pantothenate)

ANTIOXIDANTS
Pyrroloquinoline Quinone (PQQ)

ADAPTOGEN EXTRACTS
Artichoke Stem and Leaf Extract
Bacopa monnieri Leaf Extract
Coleus forskohlii Root
Ginkgo biloba Leaf Extract
Mucuna pruriens Seed
Rhodiola rosea Root

AMINO ACIDS
N-Acetyl-L-Tyrosine
Taurine
L-Theanine
Acetyl-L-Carnitine
DL-Phenylalanine

CHOLINE DONORS
Alpha GPC