Viral Eukaryogenesis theory
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Quoted By: >>11219774 >>11219828 >>11219855 >>11220153
What do you think about Viral Eukaryogenesis /sci/? Based or cringe?
For those that do not know what it is:
A paper with some arguements for it - https://www.biorxiv.org/content/10.1101/679175v1.full
In short, VE states that the eukaryotic nucleus is of viral origin - specifically, of giant virus origin. Giant viruses like Mimivirus (pic related) are very large dsDNA viruses that contain a membrane inside their capsids, inside of which DNA, mRNA and proteins are stored.
During their reproductive cycle, the inner membrane with genetic material is released from the capsid inside their hosts and a Viral Factory forms - a cell compartment in which DNA is transcripted to capped mRNA (like in Eukaryotes) which is then transported to the cytosol where it is translated by host ribosomes.
According to the theory, a giant virus with a lysogenic cycle infected an Archeon. It replicated, releasing virions outside the host, free to infect other cells. When it encountered another cell that was infected, but with a different enough strain of giant virus, it could enter the cell and fuse with the other virus (viral factory, really). Then, the DNA of both viruses would get sorted and separated mitosis-like thanks to viral DNA repair mechanisms. After billions of years, the ability to release virions was lost and host DNA was degraded and only the DNA protected by the nucleus remained.
Some things to consider:
The giant viruses contain multiple double stranded DNA that isn't circular like in Prokaryotes.
There is evidence that some of them use tubulin to position the viral factory in the middle of the cell.
They seperate transcription from translation like Eukaryotes.
They contain telomere-like sequences on the ends of their DNA.
For those that do not know what it is:
A paper with some arguements for it - https://www.biorxiv.org/content/10.1101/679175v1.full
In short, VE states that the eukaryotic nucleus is of viral origin - specifically, of giant virus origin. Giant viruses like Mimivirus (pic related) are very large dsDNA viruses that contain a membrane inside their capsids, inside of which DNA, mRNA and proteins are stored.
During their reproductive cycle, the inner membrane with genetic material is released from the capsid inside their hosts and a Viral Factory forms - a cell compartment in which DNA is transcripted to capped mRNA (like in Eukaryotes) which is then transported to the cytosol where it is translated by host ribosomes.
According to the theory, a giant virus with a lysogenic cycle infected an Archeon. It replicated, releasing virions outside the host, free to infect other cells. When it encountered another cell that was infected, but with a different enough strain of giant virus, it could enter the cell and fuse with the other virus (viral factory, really). Then, the DNA of both viruses would get sorted and separated mitosis-like thanks to viral DNA repair mechanisms. After billions of years, the ability to release virions was lost and host DNA was degraded and only the DNA protected by the nucleus remained.
Some things to consider:
The giant viruses contain multiple double stranded DNA that isn't circular like in Prokaryotes.
There is evidence that some of them use tubulin to position the viral factory in the middle of the cell.
They seperate transcription from translation like Eukaryotes.
They contain telomere-like sequences on the ends of their DNA.
