/sci/ - Science & Math » Thread #11219677

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Anonymous Thu 12 Dec 08:42:51 2019 No.11219677 View Reply Original Report

Quoted By: >>11219680 >>11219799

is chemotherapy induced brain damage iredemable? particularly for 15 y child
i m 18 now is it likely to ingite/regenerate my neurons again?

Anonymous

Anonymous Thu 12 Dec 2019 08:45:20 No.11219680 Report

Quoted By: >>11219698 >>11219721 >>11219847

>>11219677
you're not going to regenerate neurons outside of specific brain regions that aren't really associated with cognitive capacity, but you can still form new synapses and refine your synaptic pathways, which is what really matters.

What did you do that you think killed brain cells?

Anonymous

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Anonymous Thu 12 Dec 2019 09:03:08 No.11219698 Report

Quoted By:

>>11219680

>brain cells die forever

Anonymous

Anonymous Thu 12 Dec 2019 09:26:22 No.11219721 Report

Quoted By: >>11219744 >>11219791 >>11219839

>>11219680
op pic related methotrexate causes persistent depletion of oligodendrocytes lineage cells responsible od mylination (according to wiki article)
https://www.ncbi.nlm.nih.gov/pubmed/30528430?fbclid=IwAR12YqYmhWHfMzm2ULXHKYgKGRkU5v1ID8J0k4xEnIH2YZ-GxEX0nkaVHgI

Anonymous

Anonymous Thu 12 Dec 2019 09:40:13 No.11219744 Report

Quoted By: >>11219788

>>11219721
Does that cause stuff like what ms does?

Anonymous

Anonymous Thu 12 Dec 2019 10:20:47 No.11219788 Report

Quoted By:

>>11219744
Similar, but MS is a peripheral nervous system disorder. The PNS is myelinated by Schwann cells rather than oligodendrocytes

Anonymous

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Anonymous Thu 12 Dec 2019 10:27:12 No.11219791 Report

Quoted By: >>11219793

>>11219721
oligodendrocytes can be generated during adulthood

Anonymous

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Anonymous Thu 12 Dec 2019 10:29:28 No.11219793 Report

Quoted By: >>11219905

>>11219791
but neurons can't, apart from a few select areas.

and some neurons may have died, since they are in part dependent on oligodendrocytes for survival

Anonymous

Anonymous Thu 12 Dec 2019 10:33:37 No.11219799 Report

Quoted By: >>11219829

>>11219677
Which organ the chimio was targeting? Methotrexate doesn't really pass the blood brain barrier so your brain is really the least likely to be damaged by chemo.

OP Thu 12 Dec 2019 10:55:02 No.11219829 Report

Quoted By:

>>11219799
>targeting an organ
metho is an antifolate it provokes folate deficiency a factor of neurodegenracy

Anonymous

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Anonymous Thu 12 Dec 2019 11:08:11 No.11219839 Report

Quoted By:

>>11219721
I just checked the paper on sci hub:
>Blood, kidney, liver, and frontal cortex were acquired 30 min post a single 100 mg/kg methotrexate injection from 5 mice.

Wut? Isn't it like 100 times the doses used on humans? Afaik MTX is used in something like 30mg/m^2.
A kid of 15yo has a body surface of around 1,3m^2 and weigh around 50kg, that would mean 50 mg of MTX is a dose of 1mg/kg

Anonymous

Anonymous Thu 12 Dec 2019 11:16:29 No.11219847 Report

Quoted By: >>11219905

>>11219680
Youre an absolute idiot. Brain cells have been PROVEN to regrow.

Anonymous

Anonymous Thu 12 Dec 2019 11:56:19 No.11219905 Report

Quoted By:

>>11219847
yeah, in the SGV and SVZ, i.e. specific brain regions that aren't really associated with cognitive capacity.

see >>11219793
brainlet

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