>>11204316Crispr will be most useful for making therapies where cells are removed from the body, modified, and then reintroduced, or through viral delivery systems to the target. There's trials involving white blood cells modified to target cancers, cystic fibrosis and sickle cell trials are also going on. Also one for glaucoma. Basically loads of stuff going on.
Modifying embryos for monogenic diseases doesn't make much sense, as it would be far easier to just select embryos that lack the mutation - so it's only necessary in parents who are homozygous for the mutation. Even then, since most monogenic diseases are recessive, it would be cheaper and less risky to just select a heterozygous embryo. Modifying embryos to provide benefits might make some sense, there's a list somewhere with a few dozen rare mutations that confer substantial benefits, like reduced alzheimers, reduced cardiac disease etc. obviously the more edits you make the greater the risk you mess something up, so again, selection is easier and less risky.
