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Look around you. Everything is impermanent, ever-changing. Change itself seems to be the one and only true constant in nature. Why would the universe be an exception? It will change its form so drastically that it will be unrecognizable to what we know today as "the universe". It will effectively "end". But maybe something else will come in its place. And maybe just maybe, we'll become smart enough to survive all the way until this happens. This to me, is as close as you can get to "meaning" in the universe.