>>11098817Meta studies are good for this sort of thing once there are enough regular studies to give enough info when combined:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367008/Abstract
Introduction
Heart failure (HF) remains a major health problem affecting 5.7 million adults in USA. Data on the association of egg consumption with incident HF have been inconsistent. We, therefore, conducted this meta-analysis of prospective cohort studies to assess the relation of egg consumption with incident HF in the general population.
Methods
Using extensive online search, we conducted a meta-analysis of new onset HF following exposure to egg consumption. A random effects model was used and between studies heterogeneity was estimated with I2. Publication bias was assessed graphically using a funnel plot. All analyses were performed with Comprehensive Meta-Analysis (version 2.2.064).
Results
We identified four prospective cohorts for a total of 105,999 subjects and 5,059 cases of new onset HF. When comparing the highest (?1/day) to the lowest category of egg consumption, pooled relative risk of HF was 1.25 (95% confidence interval=1.12–1.39; p=0.00). There was no evidence for heterogeneity (I2 =0%) nor publication bias. On sensitivity analysis, stratification by gender differences, follow-up duration, and region where study was conducted did not alter the main conclusion.
Conclusion
Our meta-analysis suggests an elevated risk of incident HF with frequent egg consumption.
