>>11066817What effects do you mean exactly?
In my experience, the feeling of knowing and understanding everything and being almost in your grasp is just that, a feeling. It's great, but it's illusory.
Maybe you mean how (especially later in the trip, during the comedown) you can easily make and spot connections between things? Well then, try microdosing lol. It kinda helps with that, though sometimes hard to tell how much of it is placebo.
All psychedelics (might be wrong here) work on serotonin receptors in the brain. With sufficiently low doses senses are only barely affected and only your pattern recognition gets noticeably more attentive. I don't think you can go better than this - the receptors that are affected are the same everywhere in the brain, and since it travels through your blood to your brain, it gets spread quite evenly everywhere. I don't think there is any kind of barrier between neocortex and the rest of the brain that can be utilised.
Anyway - at peak, it's almost impossible to focus, so not much you can really do the.
Maybe there are other drugs that do what you want, but probably way more dangerous and/or unpleasant.
So, if you want to use psychedelics to "get smarter" or something like that, then microdose or gtfo. This, or go on a trip once in a while.