>>10965380Have a fast-reproducing poplation (bacteria, insects, etc) with well understood allele distribution in a closed controlled environment. Gradually change one parameters of the environment (say temperture). Record the number of descendants for each individual (or the size of each subcolony if you have bacterias, which are too numerous to be handled individually) and look at the alleles relating to, say, temperature resistance for each. Repeat for several generations.
This would be long and difficult but you should end with a map of the evolution of allele distribution generation-by-generation and how each individual was able to reproduce. If after a few dozens generations the proportion of temperature-resistance allele hasn't changed and/or isn't closely linked with an increase in relative number of descendants for the individuals with the most fitting allele then you'd have evidenced a dynamic contrary to evolution.
You should actually do that several times on isolated populations with different degree of severity of selection (speed and intensity of change in the parameter). You could also apply the same parameter change to isolated population and see if they undergo similar allele frequency variations. Of course this should e done on relatively simple organisms with fast reproduction cycle.
Something similar has been done with locist iirc, they developed infant-cannibalism behavior that they didn't before under some constraints (not in all colonies, but in a majority of them).
This is obviously a very rough sketch, hopefully a real biologist could make it into something doable.
