>>10908303But then they're so scarce that it will be hard for you to deliver your gene. The resistance can also become more subtle.
Some bacterial have genes that specifically target bacteriphages, kind of like a dna based immune system. With enough rats involved, a similar mechanism can arise, that simply nukes highly conserved parts of your construct, meaning you would have to start from scratch.
Then there are also conservationists that would purposely protect populations of rats because reasons, defying your extermination order