In what way do 'downers' work. I know most play a role in GABA but are there alternative ways of getting a downer experience? I've build tolerance to most benzos and even strong neuroleptics. I really need to be sedated the whole day due to a psychiatric condition.


So in what and how many different ways do sedatives work.


I've also bought lemon balm, mulungu and passionflower, I read some evidence that this works but maybe its pure placebo perhaps one of you guys know.