Producing a virus that could "target russian genes" spread by bats
Heard someone mention this as some sort of reason for WHATEVER is happening in Ukraine, dont really care, not putting up a bumper sticker, but I will get the cheap donate4cheap software/games. I dont really care about the logistics but I've been working on a transgene vectors for insects and thought what would actually be required to make this work.
I'm going to split this up into 3 main parts, then summerize here up to the text limit, finding relevant pictures to expand on each part. More than surface-level, but I'm not actually going to construct an insert, find primers nor check if the insert would logistically fit within the vector.
>insert tech, "alter russian genes" and how to drive that
>vector tech, what sort of viruses can insert into a human's germline while also infect bats via fluids
>genedrive tech, how to keep the insert within a human and "drive" it to all their chromasomes/sperm
The insert:
I'm thinking CRISPR or some sort of antisense RNA to block specific genes, although maybe replacing the genes by some sort of recombination without any additional inserts to replace (boohoo sterile purebloods). There's also that suicide gene monsanto was using to prevent cross-pollination, kill off any gametes that contain the gene of interest, I think mosquito biotech is working on that + GD.
The vector:
Not a Cwordvirus, but something that can transfect the sperm/egg cells. I think papilloma viruses do this, and tech is going in the right direction to modify the capsid proteins in simulation to bind ONLY to specific receptors (also present an albumin domain to get in the ovaries).
Infecting between bats and humans, IDK. Also needs to be targeted to avoid unnecessary mutation
The genedrive:
in addition to the insert, it needs to be able to work like a transposon and fight to get the gene on every chromatid after crossing over. Another thing that's been done in insects that could be adapted.
Heard someone mention this as some sort of reason for WHATEVER is happening in Ukraine, dont really care, not putting up a bumper sticker, but I will get the cheap donate4cheap software/games. I dont really care about the logistics but I've been working on a transgene vectors for insects and thought what would actually be required to make this work.
I'm going to split this up into 3 main parts, then summerize here up to the text limit, finding relevant pictures to expand on each part. More than surface-level, but I'm not actually going to construct an insert, find primers nor check if the insert would logistically fit within the vector.
>insert tech, "alter russian genes" and how to drive that
>vector tech, what sort of viruses can insert into a human's germline while also infect bats via fluids
>genedrive tech, how to keep the insert within a human and "drive" it to all their chromasomes/sperm
The insert:
I'm thinking CRISPR or some sort of antisense RNA to block specific genes, although maybe replacing the genes by some sort of recombination without any additional inserts to replace (boohoo sterile purebloods). There's also that suicide gene monsanto was using to prevent cross-pollination, kill off any gametes that contain the gene of interest, I think mosquito biotech is working on that + GD.
The vector:
Not a Cwordvirus, but something that can transfect the sperm/egg cells. I think papilloma viruses do this, and tech is going in the right direction to modify the capsid proteins in simulation to bind ONLY to specific receptors (also present an albumin domain to get in the ovaries).
Infecting between bats and humans, IDK. Also needs to be targeted to avoid unnecessary mutation
The genedrive:
in addition to the insert, it needs to be able to work like a transposon and fight to get the gene on every chromatid after crossing over. Another thing that's been done in insects that could be adapted.
