TLDR:
clever engineering to outwit the immune system is actually not so wise in the long term. however, not all is in vain.
dumb version:
- the glycoprotein: synthetic, lacks relevant glycans found in the natural particle itself. toxic profile.
- the construct - glycoprotein: i.e the untranslated regions of the construct. in the vaccines, they used the additions of domains that would essentially allow the glycoprotein to swerve effectively in and out of the cell. as a result, certain and very relevant signals in immune response (type1IFN) do not come across. IFN response supresses cancer. we can see how this is bad. It just so happens to lead to reactivation of previously suppressed infections as well. Additionally, codon optimization and forced ' cap-dependent pro-longed translation ' is what causes certain proteins to latch onto ribosomes more readily -> prion disease specifically due to certain motifs (GC content) eerily similar on the construct.
- once translated, what happens? exosomes, vehicles, deliver the glyoproteins which are expressed on its surface around the body. within the exosomes, specific particles called microRNAs (they function to block the synthesis of proteins) directly associated with the vaccine NOT natural infection, are different and also aid in the supression of type1IFN response by preventing the degradation of certain proteins involved in IFN response.
there are always unconsidered implications when designing a drug.
it should come as no surprise that the added time pressure of the project had negated this whole.
anyways, I was also vaccinated and have designed a vaccine candidate. I gave a partial and stupid version of the paper since it really is a huge consideration.
what will most likely happen in the future?
there will be a slightly higher susceptibility to cancers worldwide as well as neurodegenerative and cardiovascular diseases. don't worry, many scientists are working to capitalize on this at the moment.
