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Our brains will continue to shrink and level off somewhere around 1000 cm^3 on average. Of course we'll have much reduced abilities to do stuff like computation, mainly because calculators render most computational tasks obsolete. Future humans will probably only be able to add 3 digit numbers and stuff in their head at max. We'll also evolve to be hedonistic, think people who are very bad at self restraint, basically no self control. Much higher propensity for risky behavior. However, we'll likely instead have great scientific/mathematical abilities, people will essentially get an undergraduate education before high-school.
Rates of homosexuality, autism, trangenderism, and so forth will continue to skyrocket from present in the next couple hundred years. The rates will level off, drop slightly, then autism will drop off almost entirely. Homosexuality wont go away though.