>>14307482>>14307497>>14307690Actual answer that seems to be VERY promising.
Psychoplastogens are a new type of drug we're working on (I do ML at a small drug company), and it's poised to explode in the next year or so.
Psychedelics induce neuritogenesis in the prefrontal cortex, and that activity is associated with "breaking" the reward pathway in opiate addiction and especially alcohol addiction. There was some work done (ibogaine was the poster child) of an analog being made that 1) didn't have psychedelic effects, but 2) still induces neuritogenesis and (at least in mouse models) breaks the alcohol abuse cycle. These are dubbed psychoplastogens.
Grant money is FLOWING into this area, as psychedelics are an untapped resource structurally, and it's more effective than most of the shit we use today (and the safety profile is amazing).
Until psychoplastogens are on the market, though, taking LSD/Shrooms can really help remove the addiction.
t. an alcoholic researcher who cycled alcohol and opioids for years until I got out of it with a couple of shroom trips over a few months. It's not magic of course, you still have to really want to break it and try, but that "pull" of automatically stopping by the liquor store, automatically pouring that glass while explaining to yourself in your bran that you shouldn't, etc. is completely gone after a trip.
