>>14243028They won't, at least not as a chemical.
The brain will always eventually compensate for any chemical imbalances. Drugs are always followed by a crash. Addiction is the brain trying to maintain the new normal. Epileptics on anticonvulsants often relapse on a seizure as their brain returns to its normal epileptic self.
What you really need is a way to bypass the balancing system. You need to fire electrical impulses directly into the needful parts of the brain. That could be done with an invasive brain implant or some kind of electromagnetic stimulation brain cap. In you want that in pill format, you're looking for nanomachines, which are centuries ahead.