>>14127821>I really wish you luck, if someone cracks this the world will be a much nicer place.I think it's unlikely I will ever contribute anything, but at the same time I think it's one of the most important fields of our generation and everyone should take a look at it at least out of interest.
>Oh yeah, I forgot about alphafold and the new Rosetta version. Both are good for structured protein modeling which is useful. They are pretty much the state of the art for MD simulations in general. Thanks for the additional recommendations Anon.
>The idea you had about only simulating the important ones is something I've been kicking around personally for awhile. It's just a very difficult one because something can be important in like 100+ cases with 500+ more ones being edge cases involving niche responses that don't normally appear in other pathways until a stress occurs or something. I've been teaching myself differential geometry on the side because I think we can use some symmetries in spatio-temporal activation and location of various biomolecules to derive more complex behaviour. Interesting, I actually did my PhD on differential geometric methods applied on Gibbs energy surfaces (for multiscale inorganic materials surface modelling) and I was wondering if there were potential applications of the method in cell MD. I've been reading a lot of papers in this field, maybe I'll find one yours and end up pestering you with collab e-mails kek.
>Prior to superresolution microscopy that was impossible to achieve but it's getting to the point where we can make full 3D images of cells migrating in almost real time without photo-toxicity murdering all that we care about.Ah yes, I've seen those in action it's amazing. We had the group from Julich demonstrate their work to us, it's actually one of the reasons I'm looking into cells as a new test case for our methods so I can justify buying the system for our group with some leftover grant money.
