What are the side effects after you quit SNRI's, specifically Cymbalta(Duloxetine)? I ask because my gf decided to taper off Cymbalta completely. She has been completely off Cymbalta for 2 months now, and the severity of side effects is very apparent in her overall mood even her personality. I have a general understanding of how severe Cymbalta withdraw can be, but I would like to know more and if there are any long term/permanent changes that SNRI's cause.