All science is guesswork. We know next to nothing definitively, we just assume that things are true.
We assume that high pressure goes to low pressure, except when it doesn't.
We assume that insects can carry deadly bloodborne diseases, until they don't.
We assume that strong acids will fully dissolve in water, but not all of it dissolves.
We assume that light in a vacuum is the fastest speed in the universe, but technically that could be disproven eventually.
We assume that cars and such are emitting CO2 and that's warming the planet, but it could also be from a plethora of other reasons too.
Guesswork is good and all, but nothing can be proven with 100% certainty.
We assume that high pressure goes to low pressure, except when it doesn't.
We assume that insects can carry deadly bloodborne diseases, until they don't.
We assume that strong acids will fully dissolve in water, but not all of it dissolves.
We assume that light in a vacuum is the fastest speed in the universe, but technically that could be disproven eventually.
We assume that cars and such are emitting CO2 and that's warming the planet, but it could also be from a plethora of other reasons too.
Guesswork is good and all, but nothing can be proven with 100% certainty.