>A new study on mouse models has revealed transcripts encoding a longevity-determining protein that traverse through the systemic circulation in miniscule shuttles called extracellular vesicles (EVs) are a key mediator of youthfulness in muscle tissue.
>It’s common knowledge that muscles weaken with age. They become visibly smaller and less resilient to injury. Aged muscles don’t heal as well after damage because instead of restoring original muscle tissue, scar tissue is deposited instead.
>It is also widely known that infusing blood from a young animal into an aged animal, through a protocol called ‘heterochronic parabiosis’, restores youthful features in aging muscles. Heterochronic parabiosis connects the circulatory systems of two animals such that the older animal is exposed to the circulating factors from the younger animal and vice versa. What has not been known until now, is the identity of the circulating factors in young blood that mediate this rejuvenating effect.
https://www.genengnews.com/topics/translational-medicine/muscle-rejuvenating-factor-uncovered-in-circulating-extracellular-vesicles/
>It’s common knowledge that muscles weaken with age. They become visibly smaller and less resilient to injury. Aged muscles don’t heal as well after damage because instead of restoring original muscle tissue, scar tissue is deposited instead.
>It is also widely known that infusing blood from a young animal into an aged animal, through a protocol called ‘heterochronic parabiosis’, restores youthful features in aging muscles. Heterochronic parabiosis connects the circulatory systems of two animals such that the older animal is exposed to the circulating factors from the younger animal and vice versa. What has not been known until now, is the identity of the circulating factors in young blood that mediate this rejuvenating effect.
https://www.genengnews.com/topics/translational-medicine/muscle-rejuvenating-factor-uncovered-in-circulating-extracellular-vesicles/
