>>13906116>https://sci-hub.se/https://www.sciencedirect.com/science/article/abs/pii/S0014299919301943> Sigma-1 receptor agonists such as SA4503 andUMB23 have antidepressant effects in the forced-swim and tail suspension tests in mice, which are used to evaluate antidepressants
(Banister and Kassiou, 2012; Fukunaga and Moriguchi, 2017; Skuza and
Rogó, 2007; Sugimoto et al., 2012; Wang et al., 2007). In addition,
sigma-1 receptor agonists enhanced neuroplasticity, which may also be
involved in the action of antidepressants (Hayashi and Su, 2004;
Kimura et al., 2013; Takebayashi et al., 2002).
The SSRI fluvoxamine has a strong affinity for the sigma-1 receptor
(Narita et al., 1996) and enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells through stimulation of the sigma-1 receptor; its effects are blocked by sigma-1 receptor antagonism
plus another covid-protective drug has nootropic effects too and synergises with fluvoxamine (fluoxetine in a study) to enhance neurite outgrowth
https://sci-hub.se/https://www.sciencedirect.com/science/article/abs/pii/S0014299919301943you're totally missing out on very useful tools
