>>13796759balding is a very complex phenomenon. We know a lot so far.
>androgenic alopecia does not occur in castrated males>AA does not occur in absence of DHT>DHT level only correlates to AA in genetically susceptible individuals>DHT binds ~5x more strongly to AR than T>AR agonism in genetically susceptible individuals leads to upregulation of PGD2 and downregulation of PGE2>5-aR inhibition blocks T -> DHT turnoverThe problem is to take all this information and create a treatment that doesn't interfere with any other systems in the body. T, DHT, and PGD2 are important hormones. So far, we know you can block 5-aR or you can competitively inhibit PGD2 receptors and both of those will stop AA, but the latter is understudied and the former will obviously cause androgen related side effects. Moreover, the relative effects of DHT vs T binding at other AR sites around the body is also probably genetically determined, so it will have varying effects in different people. And the problem with PGD2 is simply blocking a receptor by adding a ligand will lead to a pretty strong tolerance effect, requiring constant increase in concentration, and the AA will bounce back very intensely if you remove the ligand. Also, hairs that have been in telogen for too long are hard to recover, so saving guys' really far gone hair requires cloning or something. But you could always just get an HT. HTs are really good and cheap these days.
