ok so lets say i am taking 5mg aripiprazole daily but i am a known cyp2d6 poor metabolizer
pic related the box plot shows mean change in AUC is about 2x for genetically CYP2D6 poor metabolizer
ok so "the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time "
ok so is 2x increase in AUC equivalent to taking 2x the dose daily so the cyp2d6 poor metabolizer effectively would be taking 10mg?
would 10mg dose daily have 2x the AUC of 5mg daily?
so like if f(t) is the function "describing the variation of a drug concentration in blood plasma as a function of time" for 5mg daily, and g(t) for 10mg daily
then is g(t) = 2(t)? which would make the AUC of g = 2 * AUC of f because of the constant multiple rule
pic related the box plot shows mean change in AUC is about 2x for genetically CYP2D6 poor metabolizer
ok so "the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time "
ok so is 2x increase in AUC equivalent to taking 2x the dose daily so the cyp2d6 poor metabolizer effectively would be taking 10mg?
would 10mg dose daily have 2x the AUC of 5mg daily?
so like if f(t) is the function "describing the variation of a drug concentration in blood plasma as a function of time" for 5mg daily, and g(t) for 10mg daily
then is g(t) = 2(t)? which would make the AUC of g = 2 * AUC of f because of the constant multiple rule