>>13644896>>13648224TTS is linked to only AstraZeneca and the J&J vaxes, not the two mRNA vaxes. It results from the mysterious production of antibodies against platelet factor 4 (PF4).
It doesn't appear spike-mediated: while the AstraZeneca vax uses the same spike protein as the virus, J&J uses a prefusion-stabilized form like the two mRNA vaxes.
If it's not a component of the adenovirus causing the clotting, my guess is that it's the excipient ingredient polysorbate-80, which is the only common excipient ingredient that AstraZeneca and J&J share (aside from water, ethanol, and sodium chloride) and which the two mRNA vaxes don't contain. Polysorbate-80 is a surfactant that's been known for decades to enhance an anti-clotting process known as fibrinolysis, which may make it seem strange as a possible culprit for clotting, until you remember that blood thinners such as heparin can also cause clotting (known as heparin-induced thrombocytopenia).
There's no guarantee that taking a blood thinner will help -- it could conceivably make thrombotic events more likely via pathways suggested above. If you get the AstraZeneca or J&J vax, your chances of dying from TTS are around 1 in 1.35 million by Australian data, but if you don't trust those numbers, the only proactive thing you can really do other than avoiding these two vaxes in favor of another vax (myocarditis is far easier to treat medically than TTS and generally far less serious) is to find a doctor willing to run frequent platelet counts and D-dimer tests over the course of a month.
