How is caffeine healthy when it kills your brain?!
No.13550598 ViewReplyOriginalReport
Quoted By: >>13551815 >>13551824 >>13552291 >>13552298 >>13553048
>Caffeine is a commonly used neurostimulant that also produces cerebral vasoconstriction by antagonizing adenosine receptors. Chronic caffeine use results in an adaptation of the vascular adenosine receptor system presumably to compensate for the vasoconstrictive effects of caffeine. We investigated the effects of caffeine on cerebral blood flow (CBF) in increasing levels of chronic caffeine use. Low (mean = 45 mg/day), moderate (mean = 405 mg/day), and high (mean = 950 mg/day) caffeine users underwent quantitative perfusion magnetic resonance imaging on four separate occasions: twice in a caffeine abstinent state (abstained state) and twice in a caffeinated state following their normal caffeine use (native state). In each state, there were two drug conditions: participants received either caffeine (250 mg) or placebo. Gray matter CBF was tested with repeated-measures analysis of variance using caffeine use as a between-subjects factor, and correlational analyses were conducted between CBF and caffeine use. Caffeine reduced CBF by an average of 27% across both caffeine states. In the abstained placebo condition, moderate and high users had similarly greater CBF than low users; but in the native placebo condition, the high users had a trend towards less CBF than the low and moderate users. Our results suggest a limited ability of the cerebrovascular adenosine system to compensate for high amounts of daily caffeine use.
>A 250 mg dose of caffeine has been shown to reduce resting cerebral blood flow (CBF) between 22% and 30%
>>Caffeine reduced gray matter CBF by 27% to approximately 60 ml/100 g of tissue/min across all caffeine users
How can someone justify using caffeine after seeing stuff like this? It's a vasoconstrictor, it'll turn your brain into mush.
>A 250 mg dose of caffeine has been shown to reduce resting cerebral blood flow (CBF) between 22% and 30%
>>Caffeine reduced gray matter CBF by 27% to approximately 60 ml/100 g of tissue/min across all caffeine users
How can someone justify using caffeine after seeing stuff like this? It's a vasoconstrictor, it'll turn your brain into mush.
