>The epigenome of a cell decides it's identity by turning certain genes on and off
>As an individual gets older, there are epigenetic alterations that result in cells losing their normal function.
>This is a big reason for why older people have all kinds of dysfunctional cells
>Inserting genes for yamanaka factors into an adult cell and having them be expressed results in the cell becoming a pluripotent stem cell again
>If you stop the expression of yamanaka factors short, the adult cell doesn't revert all the way back to being a stem cell but becomes observably younger (you look can look at the epigenome to see this)
>This has been done with mouse neurons
>The cells also regained functions you'd normally only see in young cells (way better ability to regenerate in the case of the mouse nerons, nerve damages in adult mammals almost don't heal at all)
>Also no cancer developed in the mice this was tested on
So essentially we have the ability to rejuvenate cells, turn them back to a young state again where they have better regenerative capabilities and lack the dysfunctions typical of cells that are older. This tech is basically the fountain of youth.
Here's a thing such technology could be used for:
>Insert yamanaka factors into the tissues of the penis via viral vector that specifically targets those tissues
>Stop the expression of these genes before the penis turns into a blob of stem cells
>The penis is now "younger" and has regained certain functions it had during puberty
>It now grows in response to certain hormones again
>And voilà you have created high quality penis enlargement, you now get to be filthy rich
Thoughts?
>As an individual gets older, there are epigenetic alterations that result in cells losing their normal function.
>This is a big reason for why older people have all kinds of dysfunctional cells
>Inserting genes for yamanaka factors into an adult cell and having them be expressed results in the cell becoming a pluripotent stem cell again
>If you stop the expression of yamanaka factors short, the adult cell doesn't revert all the way back to being a stem cell but becomes observably younger (you look can look at the epigenome to see this)
>This has been done with mouse neurons
>The cells also regained functions you'd normally only see in young cells (way better ability to regenerate in the case of the mouse nerons, nerve damages in adult mammals almost don't heal at all)
>Also no cancer developed in the mice this was tested on
So essentially we have the ability to rejuvenate cells, turn them back to a young state again where they have better regenerative capabilities and lack the dysfunctions typical of cells that are older. This tech is basically the fountain of youth.
Here's a thing such technology could be used for:
>Insert yamanaka factors into the tissues of the penis via viral vector that specifically targets those tissues
>Stop the expression of these genes before the penis turns into a blob of stem cells
>The penis is now "younger" and has regained certain functions it had during puberty
>It now grows in response to certain hormones again
>And voilà you have created high quality penis enlargement, you now get to be filthy rich
Thoughts?