The stimulatory effect on the CNS caused by amphetamine, methamphetamine, cocaine and other recreational compounds seems incredibly confusing.
The role of the VMAT protein is to transport monoamine neurotransmitters into vesicles, where VMAT2 (The main target of the above recreationals) are expressed in the CNS, compared to VMAT1's primary expression.
Given that recreationals INHIBIT VMAT2, should synaptic firing activity decrease, causing a CNS depression, due to a lower concentration of intrasynaptic concentrations of primarily catecholamine monoamine neurotransmitters?
Cheers.