>>13419930>so there is the spike protein in the old inactive virus.They ALL use spike proteins. The only difference is that Pfizer, Moderna, J&J, and apparently Novavax use a modified spike protein intended for safety (it's known as the 2P spike protein, because it introduces two proline modifications to the natural viral spike protein), whereas AstraZeneca uses the spike protein from the virus itself.
Now, my working theory has been that the TTS and general clotting cases seen with AstraZeneca were spike-mediated and the ITP and myocarditis cases seen with the mRNA vaccines were autoimmune-mediated, but it seems that the J&J vax (which, again, uses the safety-modified spike protein) has a TTS adverse-event profile too, so it's probably not the AstraZeneca natural spike that makes it more dangerous than other vaxes, which is a concern for Novavax because it's closer to AstraZeneca on the technology family tree than other vaxes are.
