Sadly I don't think Bamco will ever do another male x male relationship like that in their future games. Zesty tainted everything associated with it quite badly in Japan.
The upcoming game has sparse information out but there's a runaway princess heroine and stoic, amnesiac male lead paired with her. Seems generic but I'm hoping for the best. At the very least, I hope they keep a varied and balanced cast instead of only aiming for straight males. They seem aware that women like the series too based on the comments on why they did away with the cute monster designs so, there's hope.
I hope they keep the skits and strong character interactions despite rehauling the Tales of line; they're what makes every Tales game worth playing even if the combat and/or story fall flat.