>>7684229From a pure flight perspective, only a little, but it does matter some. Longer ships have more angular moment of inertia and so are harder to turn and stop, but give you a longer lever arm to turn with if you have thrusters on the ends
And if you have more thrusters clustered in one place, this gets you a larger thrust and reduces duplication and complexity, but means you can only effectively accelerate in one axis and must turn the ship to thrust in a different direction.
Your surface area to volume ratio also affects how rapidly you can shed excess heat without having to have big, flimsy radiators sticking out.