/sci/ - Science & Math » Thread #10671638

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Anonymous Sat 25 May 15:33:33 2019 No.10671638 View Reply Original Report

Quoted By: >>10671647 >>10671925

https://www.nydailynews.com/news/national/man-meth-fights-cops-masturbating-police-article-1.1557876

I didn't realize that stimulants would make a taser ineffective against someone, I guess because its enhancing the inhibitory parts of the brain and their ability to override the pain?

Maybe its something else like pain integrating into consciousness differently (e,g, in a non-debilitating way) while in psychosis?

Anonymous

Anonymous Sat 25 May 2019 15:37:06 No.10671647 Report

Quoted By: >>10671654 >>10671656 >>10671662 >>10671697 >>10671877

>>10671638
Is there such a thing as a drug that makes you feel no physical pain but makes you decently reasonable and not completely detached from reality at the same time?

Anonymous

Anonymous Sat 25 May 2019 15:41:46 No.10671654 Report

Quoted By: >>10671663

>>10671647
Morphine?

Anonymous

Anonymous Sat 25 May 2019 15:44:30 No.10671656 Report

Quoted By:

>>10671647
Why would you want that? Pain is an advantage.

Anonymous

Anonymous Sat 25 May 2019 15:48:55 No.10671662 Report

Quoted By: >>10671668

>>10671647
you really really dont want that unless youre in some life or death situation
you'll over exhaust yourself and probably hurt yourself while youre at it

Anonymous

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Anonymous Sat 25 May 2019 15:49:28 No.10671663 Report

Quoted By: >>10671674 >>10671678 >>10671698

>>10671654
But that makes you completely inoperative on your daily life. What about a drug or compound that doesn't alter much your physical ability while inhibiting pain? Have you ever heard about Congenital insensitivity to pain (CIP)?

>For people with this disorder, cognition and sensation are otherwise normal; for instance, patients can still feel discriminative touch (though not always temperature[3]), and there are generally no detectable physical abnormalities.

>this disorder can be in the voltage-gated sodium channel SCN9A (Nav1.7).[6] Patients with such mutations are congenitally insensitive to pain and lack other neuropathies. There are three mutations in SCN9A: W897X, located in the P-loop of domain 2; I767X, located in the S2 segment of domain 2; and S459X, located in the linker region between domains 1 and 2. This results in a truncated non-functional protein. Nav1.7 channels are expressed at high levels in nociceptive neurons of the dorsal root ganglia. As these channels are likely involved in the formation and propagation of action potentials in such neurons, it is expected that a loss of function mutation in SCN9A leads to abolished nociceptive pain propagation.[7]

It'd be nice if you could take a pill or any kind of medication that just makes SCN9A sodium channel inoperative. Imagine super soldiers with this

Anonymous

Anonymous Sat 25 May 2019 15:55:00 No.10671668 Report

Quoted By: >>10671678

>>10671662
>you'll over exhaust yourself and probably hurt yourself while youre at it
This. I remember once when I was a kid and they anesthetized my lips because of a surgery. I absolutely did not feel pain on my lips, and I started to like the texture of my lips meat, so I just started to chew my lips like a retard, and it felt good. Next day I had horrible pain and inflammation kek

Anonymous

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Anonymous Sat 25 May 2019 15:58:41 No.10671674 Report

Quoted By:

>>10671663
Homozygous microdeletion in the FAAH-OUT pseudogene of the fatty acid amide hydrolase chromosomal region that is expressed in the brain and dorsal root ganglia was identified as the cause of congenital analgesia in a single individual (as of 2019). The individual experienced lifelong insensitivity to pain and was oblivious to cuts and burns, did not experience pain during childbirth, did not experience pain from degeneration of a hip that required hip replacement surgery, and did not require analgesics for postoperative pain.

>Furthermore, the individual exhibited expedited wound healing and reduced scarring, could not sense heat from chili peppers, did not experience depression, fear, and anxiety and lacked a normal fear response to erratic and aggressive behaviour.

>did not experience depression, fear, and anxiety

So comfy...

Anonymous

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Anonymous Sat 25 May 2019 15:59:14 No.10671678 Report

Quoted By:

>>10671663
You want to take something like that daily? What do you think your brain is a soup?

>It'd be nice if you could take a pill or any kind of medication that just makes SCN9A sodium channel inoperative. Imagine super soldiers with this

Ever been in a car crash? A motorcycle crash? You don't feel shit to the point where people that come to drag you out of the car/street tell you to avoid standing on your own because your entire legs might be shattered and you wouldn't know.

I can't imagine what combat is like but pain is there when it's necessary, to prevent you from doing stupid shit, and nowhere to be found when it's useless. See >>10671668

There's a reason people say "adrenaline is one hell of a drug". It's no meme, it really fucking is.

Anonymous

Anonymous Sat 25 May 2019 16:06:21 No.10671697 Report

Quoted By: >>10671704

>>10671647
No, that's the holy grail of pain inhibitor drug research. There are many companies working on it now, trying to induce the same effects of congenital insensitivity to pain on a temporary basis. This research could lead to non-addictive pain killers.

Anonymous

Anonymous Sat 25 May 2019 16:07:23 No.10671698 Report

Quoted By: >>10671704

>>10671663
There are already drug companies working on this.

Anonymous

Anonymous Sat 25 May 2019 16:09:48 No.10671704 Report

Quoted By: >>10671978

>>10671697
>>10671698
Will this ever be available? if so, when do you think it will be?

Anonymous

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Anonymous Sat 25 May 2019 16:13:01 No.10671710 Report

Quoted By:

Anonymous

Anonymous Sat 25 May 2019 17:17:01 No.10671877 Report

Quoted By:

>>10671647
Vicodin?

Anonymous

Anonymous Sat 25 May 2019 17:32:42 No.10671925 Report

Quoted By:

>>10671638
>I didn't realize that stimulants would make a taser ineffective against someone, I guess because its enhancing the inhibitory parts of the brain and their ability to override the pain?
No, the taser didn't hit correctly, probably fired in the wrong spot. With a taser it's not the pain that's bringing you down, or at least it's not only the pain.

Anonymous

Anonymous Sat 25 May 2019 17:49:27 No.10671978 Report

Quoted By:

>>10671704
I'd say easily by 2025 if phase 3 drug trials go well. (it already passed phase 2, which is the phase most likely to fail). It will start as treatment for acute pain (pain from injuries and surgeries, etc), since trials for long term pain are much more difficult and lengthy.
https://www.vrtx.com/story/third-positive-phase-2-proof-concept-study-vx-150
https://www.pfizer.com/news/press-release/press-release-detail/pfizer_and_lilly_announce_top_line_results_from_long_term_phase_3_study_of_tanezumab_in_patients_with_osteoarthritis

Other analgesics in development:
https://en.wikipedia.org/wiki/List_of_investigational_analgesics

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