No. If anything, it's much easier to create vibrant colors, gradients and good shading. You have the ability to erase while inking, and the stabilizer too. (Though I wouldn't recommend using that as a crutch to a /beg/)
You will only have difficulty with something you aren't used to. There are artists out there who are better drawing with a mouse than by hand.
Getting used to working digital takes a year at max, probably not half as long.
If you're apprehensive about going full digital, you can keep sketching traditionally. That also helps you maintain your skills in trad.