Depends when the fight takes place. If it is at any time after Tiberium appeared, where Kane is openly leading the brotherhood, Hydra wouldn't have a chance.
If it is before Tiberium, then Nod wouldn't have the economical base for a proper fight, and if it is during any of the periods when Kane was "dead", Nod would be too splintered for a proper fight.
>>99967387It's spelled Nod, not NOD (it's not an acronym, unlike GDI). And Kane is not a god, merely his immortal prophet, guiding humanity towards ascension.