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The magical realism of the original book is much easier to buy in comic form. The simplified character designs and slightly cartoonish world make it easier to buy. A cartoon would be a much better choice for adaptation.
You COULD make it into live-action, but that would require extraordinary talent, and this movie doesn't look like it cuts the mustard.
Also the actor for Barbara sounds too sincere and serious. I always imagined her speaking very sardonically, like she really believes she's surrounded by fools.
Overall, unless this gets rave reviews, I will not be seeing it.